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GLP-1 receptor agonist combinations with other weight loss agents have been explored in limited contexts

Lilly has demonstrated their ability to bring complex peptide therapies through the regulatory process, and their phase 3 TRIUMPH trial program for retatrutide includes multiple studies across different patient populations

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Cell 81 , 49644978.e4968 (2021)

In phase 2 trials, cagrilintide alone produced dose-dependent reductions in body weight, with participants on the highest dose (4.5 mg weekly) losing roughly 10-15% of body weight over 26 weeks